Effect of Trichostatin A on Bleomycin Induced Pulmonary Fibrosis in Mice and its Mechanism
نویسندگان
چکیده
To investigate the effect and mechanism of trichostatin A on bleomycin induced pulmonary fibrosis in mice compared with dexamethasone pirfenidone is objective study. C57 black 6 were instilled intranasal to establish model. They divided into five groups: Control group, model group group. Hematoxylin eosin staining Masson’s was conducted; expression related proteins each observed by immunohistochemistry Western blotting. showed that lung tissue damaged varying degrees, interstitial protein deposition, basal cell hyperplasia a large number macrophage infiltration alveolar cavity. The injury least. vimentin, collagen-I, alpha smooth muscle actin other increased significantly, above intervention treatment decreased especially suppressor mothers against decapentaplegic homolog 7 significantly group; there no significant difference p38-mitogen-activated kinase messenger RNA such as collagen-I peaked 14th d after modeling. Trichostatin could inhibit progression inhibiting activity histone deacetylase 1, while 1 activate transforming growth factor beta-1/suppressor pathway, involved fibrosis. Dexamethasone not delay or improve fibrosis, even aggravate
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2023
ISSN: ['0250-474X', '1998-3743']
DOI: https://doi.org/10.36468/pharmaceutical-sciences.spl.630